User profiles for Yuanyuan Zhang

Yuanyuan Zhang

- Verified email at pku.edu.cn - Cited by 6297

Yuanyuan Zhang

- Verified email at ucl.ac.uk - Cited by 4925

Yuanyuan Zhang

- Verified email at bit.edu.cn - Cited by 3889

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

R Yan, Y Zhang, Y Li, L Xia, Y Guo, Q Zhou - Science, 2020 - science.org
Angiotensin-converting enzyme 2 (ACE2) is the cellular receptor for severe acute respiratory
syndrome–coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2) that is …

[PDF][PDF] Landscape of infiltrating T cells in liver cancer revealed by single-cell sequencing

…, Y Zhang, X Guo, B Kang, R Hu, JY Huang, Q Zhang… - Cell, 2017 - cell.com
Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform deep …

Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing

X Guo, Y Zhang, L Zheng, C Zheng, J Song, Q Zhang… - Nature medicine, 2018 - nature.com
Cancer immunotherapies have shown sustained clinical responses in treating non-small-cell
lung cancer 1 , 2 – 3 , but efficacy varies and depends in part on the amount and properties …

[PDF][PDF] Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

Y Zhang, H Chen, H Mo, X Hu, R Gao, Y Zhao, B Liu… - Cancer cell, 2021 - cell.com
In triple-negative breast cancer (TNBC), the benefit of combining chemotherapy with
checkpoint inhibitors is still not very clear. We utilize single-cell RNA- and ATAC-sequencing to …

[HTML][HTML] The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

Y Zhang, Z Zhang - Cellular & molecular immunology, 2020 - nature.com
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune …

A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

…, R Yan, J Zhang, G Zhang, Y Zhang, M Hao, Z Zhang… - Science, 2020 - science.org
Developing therapeutics against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
could be guided by the distribution of epitopes, not only on the receptor binding …

From tree house to barracks: The social life of guilds in World of Warcraft

…, N Ducheneaut, L Xiong, Y Zhang… - Games and …, 2006 - journals.sagepub.com
A representative sample of players of a popular massively multiplayer online game (World
of Warcraft) was interviewed to map out the social dynamics of guilds. An initial survey and …

Search-based software engineering: Trends, techniques and applications

M Harman, SA Mansouri, Y Zhang - ACM Computing Surveys (CSUR), 2012 - dl.acm.org
In the past five years there has been a dramatic increase in work on Search-Based Software
Engineering (SBSE), an approach to Software Engineering (SE) in which Search-Based …

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

L Zhang, X Yu, L Zheng, Y Zhang, Y Li, Q Fang, R Gao… - Nature, 2018 - nature.com
T cells are key elements of cancer immunotherapy 1 but certain fundamental properties,
such as the development and migration of T cells within tumours, remain unknown. The …

Hybridization of MOFs and polymers

T Kitao, Y Zhang, S Kitagawa, B Wang… - Chemical Society …, 2017 - pubs.rsc.org
Metal–organic frameworks (MOFs) have received much attention because of their attractive
properties. They show great potential applications in many fields. An emerging trend in MOF …