Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients

X Ni, M Zhuo, Z Su, J Duan, Y Gao… - Proceedings of the …, 2013 - National Acad Sciences
Circulating tumor cells (CTCs) enter peripheral blood from primary tumors and seed metastases.
The genome sequencing of CTCs could offer noninvasive prognosis or even diagnosis, …

Variable intra-tumor genomic heterogeneity of multiple lesions in patients with hepatocellular carcinoma

R Xue, R Li, H Guo, L Guo, Z Su, X Ni, L Qi, T Zhang… - Gastroenterology, 2016 - Elsevier
Background & Aims Many patients with hepatocellular carcinoma (HCC) have multiple
lesions (primary tumors, intrahepatic metastases, multiple occurrences, satellite nodules, and …

Single-cell sequencing deciphers a convergent evolution of copy number alterations from primary to circulating tumor cells

Y Gao, X Ni, H Guo, Z Su, Y Ba, Z Tong, Z Guo… - Genome …, 2017 - genome.cshlp.org
Copy number alteration (CNA) is a major contributor to genome instability, a hallmark of cancer.
Here, we studied genomic alterations in single primary tumor cells and circulating tumor …

Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype

I Serganova, A Rizwan, X Ni, SB Thakur, J Vider… - Clinical Cancer …, 2011 - AACR
Purpose: We compared the metabolic profiles and the association between LDH-A expression
and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR …

Multicolor stimulated Raman scattering microscopy

FK Lu, M Ji, D Fu, X Ni, CW Freudiger, G Holtom… - Molecular …, 2012 - Taylor & Francis
Stimulated Raman scattering (SRS) microscopy has opened up a wide range of biochemical
imaging applications by probing a particular Raman-active molecule vibrational mode in …

[HTML][HTML] Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer

…, DR Aberle, V Agopian, SHB Han, X Ni… - Nature …, 2022 - nature.com
Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free
DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to …

Inferring the evolution and progression of small-cell lung cancer by single-cell sequencing of circulating tumor cells

Z Su, Z Wang, X Ni, J Duan, Y Gao, M Zhuo, R Li… - Clinical Cancer …, 2019 - AACR
Purpose: Genomic analyses of small-cell lung cancer (SCLC) are limited by the availability of
tumor specimens. This study aimed to investigate the suitability of single-cell sequencing of …

Comprehensive tissue deconvolution of cell-free DNA by deep learning for disease diagnosis and monitoring

S Li, W Zeng, X Ni, Q Liu, W Li… - Proceedings of the …, 2023 - National Acad Sciences
Plasma cell-free DNA (cfDNA) is a noninvasive biomarker for cell death of all organs. Deciphering
the tissue origin of cfDNA can reveal abnormal cell death because of diseases, which …

Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors

…, I Serganova, R Khanin, H Karabeber, X Ni… - Clinical Cancer …, 2013 - AACR
Purpose: To investigate the relationship between lactate dehydrogenase A (LDH-A) expression,
lactate concentration, cell metabolism, and metastases in murine 4T1 breast tumors. …

Lignin-based multi-channels carbon nanofibers@ SnO2 nanocomposites for high-performance supercapacitors

M Cao, W Cheng, X Ni, Y Hu, G Han - Electrochimica Acta, 2020 - Elsevier
The lignin-based multi-channels carbon nanofibers (MCNFs) @ SnO 2 nanocomposites
with various microstructures are synthesized via co-electrospinning by regarding Poly (vinyl …