Background Hepatic encephalopathy is a chronically debilitating complication of hepatic
cirrhosis. The efficacy of rifaximin, a minimally absorbed antibiotic, is well documented in the …

The tumor suppressor p53, a sensor of multiple forms of cellular stress, is regulated by post-translational
mechanisms to induce cell-cycle arrest, senescence, or apoptosis. We …

All-solid-state lithium (Li) metal and lithium-ion batteries (ASSLBs) with inorganic solid-state
electrolytes offer improved safety for electric vehicles and other applications. However, …

Fast-food marketing to children is considered a contributor to childhood obesity. Effects of
marketing on parents may also contribute to childhood obesity. The authors explore relevant …

Soluble guanylate cyclases (sGCs) function as heme sensors that selectively bind nitric oxide
(NO), triggering reactions essential to animal physiology. Recent discoveries place sGCs …

Several recent studies have demonstrated that the metabolism of energy substrates takes
place in multiple compartments in both astrocytes and synaptic terminals from brain. There are …

Rationale: Structural risk factors for obstructive sleep apnea syndrome (OSAS) in adolescents
have not been well characterized. Because many adolescents with OSAS are obese, we …

The heme cofactor in soluble guanylate cyclase (sGC) is a selective receptor for NO, an
important signaling molecule in eukaryotes. The sGC heme domain has been localized to the N-…

Importance RecurrentClostridioides difficileinfection (CDI) is a debilitating disease leading
to poor health-related quality of life (HRQOL), loss of productivity, anxiety, and depression. …

A series of aza-5[H]-phenanthridin-6-ones were synthesized and evaluated as inhibitors of
poly ADP-ribose polymerase-1 (PARP-1). Inhibitory potency of the unsubstituted aza-5[H]-…