Actin filament assembly typically occurs in association with cellular membranes. A large
number of proteins sit at the interface between actin networks and membranes, playing diverse …

The barbed and pointed ends of the actin filament (F-actin) are the sites of growth and shrinkage
and the targets of capping proteins that block subunit exchange, including CapZ at the …

Autophagy is a degradative pathway required to maintain homeostasis. Neuronal
autophagosomes form constitutively at the axon terminal and mature via lysosomal fusion during …

Arp2/3 complex generates branched actin networks that drive fundamental processes such
as cell motility and cytokinesis. The complex comprises seven proteins, including actin-…

Cortactin coactivates Arp2/3 complex synergistically with WASP-family nucleation-promoting
factors (NPFs) and stabilizes branched networks by linking Arp2/3 complex to F-actin. It is …

SWI/SNF chromatin remodelers modify the position and spacing of nucleosomes and, in
humans, are linked to cancer. To provide insights into the assembly and regulation of this …

Hsp104 is an AAA+ protein disaggregase, which can be potentiated via diverse mutations
in its autoregulatory middle domain (MD) to mitigate toxic misfolding of TDP-43, FUS, and α-…

Actin is the most abundant protein in the cytoplasm of eukaryotic cells and interacts with
hundreds of proteins to perform essential functions, including cell motility and cytokinesis. …

Eukaryotic cells have diverse protrusive and contractile actin filament structures, which compete
with one another for a limited pool of actin monomers. Numerous actin-binding proteins …

Spotted fever group Rickettsia undergo actin-based motility inside infected eukaryotic cells
using Sca2 (surface cell antigen 2): an ∼ 1800 amino-acid monomeric autotransporter …