Sirtuins are a highly conserved family of proteins whose activity can prolong the lifespan of
model organisms such as yeast, worms and flies. Mammals contain seven sirtuins (SIRT1–7) …

Protein acetylation is a well-studied regulatory mechanism for several cellular processes,
ranging from gene expression to metabolism. Recent discoveries of new post-translational …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Sirtuins are NAD + -dependent protein deacetylases. They mediate adaptive responses to a
variety of stresses, including calorie restriction and metabolic stress. Sirtuin 3 (SIRT3) is …

Concentrations of acetyl–coenzyme A and nicotinamide adenine dinucleotide (NAD + )
affect histone acetylation and thereby couple cellular metabolic status and transcriptional …

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many
organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here…

… This paper builds on related research by Hirschey [10], Jose, Nichols, and Stevens [12], …
subsidy for advertising and R&D intensive firms (see Hirschey and Weygandt [11]). Therefore, …

A major cause of aging and numerous diseases is thought to be cumulative oxidative stress,
resulting from the production of reactive oxygen species (ROS) during respiration. Calorie …

… and generously made available to this study by Kenneth M. Harlan. See Hirschey [1982]
for a detailed description. Growth is measured as the average annual rate of change in sales …

Acetylation is increasingly recognized as an important metabolic regulatory posttranslational
protein modification, yet the metabolic consequence of mitochondrial protein …