Molecular predictors of outcome with gefitinib in a phase III placebo-controlled study in advanced non–small-cell lung cancer

FR Hirsch, M Varella-Garcia, PA Bunn Jr… - Journal of clinical …, 2006 - ascopubs.org
Purpose The phase III Iressa Survival Evaluation in Lung Cancer (ISEL) trial compared gefitinib
with placebo in 1,692 patients with refractory advanced non–small-cell lung cancer. We …

Exponential lower bounds for finding brouwer fix points

MD Hirsch, CH Papadimitriou, SA Vavasis - Journal of Complexity, 1989 - Elsevier
… This work builds upon an extended abstract of two of the authors (Hirsch and Vavasis, 1987)
presented at the IEEE Symposium on Foundations of Computer Science. The results below …

Anammox Bacterial Diversity in Various Aquatic Ecosystems Based on the Detection of Hydrazine Oxidase Genes (hzoA/hzoB)

MD Hirsch, ZT Long, B Song - Microbial ecology, 2011 - Springer
Anammox bacteria belonging to the phylum Planctomycetes are responsible for N removal
through NH 4 + oxidation coupled with NO 2 − reduction. Microbial diversity and ecology of …

A geometric approach to a class of equilibrium existence theorems

MD Hirsch, M Magill, A Mas-Colell - Journal of Mathematical Economics, 1990 - Elsevier
In this paper we propose a general mathematical approach to existence problems in economics
based on the geometry of vector bundles and the methods of intersection theory. The …

A new algorithm for recognizing the unknot

JS Birman, MD Hirsch - Geometry & Topology, 1999 - msp.org
The topological underpinnings are presented for a new algorithm which answers the
question:“Is a given knot the unknot?” The algorithm uses the braid foliation technology of …

[HTML][HTML] International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of …

…, JHM Austin, H Asamura, VW Rusch, FR Hirsch… - Journal of thoracic …, 2011 - Elsevier
Introduction: Adenocarcinoma is the most common histologic type of lung cancer. To
address advances in oncology, molecular biology, pathology, radiology, and surgery of lung …

[PDF][PDF] A method for measuring picosecond phenomena in photolabile species: the emission lifetime of bacteriorhodopsin

MD Hirsch, MA Marcus, A Lewis, H Mahr, N Frigo - Biophysical journal, 1976 - cell.com
We have measured the emission lifetime of bacteriorhodopsin at physiological temperatures
to be 15 +/- 3 ps using a technique which employs a mode-locked dye laser, a sum …

Modifications in optoelectronic behavior of plasma-deposited amorphous semiconductor alloys via impurity incorporation

…, FJ Kampas, PE Vanier, MD Hirsch - Journal of Non-Crystalline …, 1980 - Elsevier
We discuss electronic properties of plasma-deposited a-Si:H alloys as functions of oxygen
and nitrogen impurities. Over a wide range of processing conditions, features displayed by the …

Chronic ethanol intake decreases vasopressin mRNA content in the rat hypothalamus: a PCR study

PP Sanna, DP Folsom, MJ Barizo, MD Hirsch… - Molecular brain …, 1993 - Elsevier
Vasopressin mRNA content was studied by quantitative reverse transcriptase-polymerase
chain reaction (RT-PCR) in the hypothalami of rats chronically treated with ethanol (EtOH). …

Endoproteolytic conversion of β-endorphin-1-31 to β-endorphin-1-27 potentiates its central cardioregulatory activity

MD Hirsch, WR Millington - Brain research, 1991 - Elsevier
Brain neurons that express the pro-opiomelanocortin gene secrete multiple forms of β-endorphin
(βE) which subserve diverse bioregulatory processes. βE-1-31, for example, is a potent …