[HTML][HTML] Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: a perspective on the contributions of apoptosis and necrosis
LJ Martin, NA Al-Abdulla, AM Brambrink, JR Kirsch… - Brain research …, 1998 - Elsevier
In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …
[HTML][HTML] Mammographic density and breast cancer risk: current understanding and future prospects
Variations in percent mammographic density (PMD) reflect variations in the amounts of
collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is …
collagen and number of epithelial and non-epithelial cells in the breast. Extensive PMD is …
Breast tissue composition and susceptibility to breast cancer
Breast density, as assessed by mammography, reflects breast tissue composition. Breast
epithelium and stroma attenuate x-rays more than fat and thus appear light on mammograms …
epithelium and stroma attenuate x-rays more than fat and thus appear light on mammograms …
[HTML][HTML] Mammographic density and the risk and detection of breast cancer
Background Extensive mammographic density is associated with an increased risk of breast
cancer and makes the detection of cancer by mammography difficult, but the influence of …
cancer and makes the detection of cancer by mammography difficult, but the influence of …
Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis
The pathogenesis of sporadic amyotrophic lateral sclerosis (ALS) is unknown, but defects in
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…
synaptosomal high‐affinity glutamate transport have been observed. In experimental models…
[HTML][HTML] Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
Background. Amyotrophic lateral sclerosis (ALS) is a chronic degenerative neurologic
disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. …
disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. …
Different immune cells mediate mechanical pain hypersensitivity in male and female mice
A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling
is essential for chronic pain hypersensitivity. Using multiple approaches, we found that …
is essential for chronic pain hypersensitivity. Using multiple approaches, we found that …
Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.
…, HC Pant, RO Brady, LJ Martin… - Proceedings of the …, 1996 - National Acad Sciences
Although cyclin-dependent kinase 5 (Cdk5) is closely related to other cyclin-dependent
kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and …
kinases, its kinase activity is detected only in the postmitotic neurons. Cdk5 expression and …
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
In the brains of aged humans and cases of Alzheimer disease, deposits of amyloid in senile
plaques are located in proximity to nerve processes. The principal component of this …
plaques are located in proximity to nerve processes. The principal component of this …
Olfactory exposure to males, including men, causes stress and related analgesia in rodents
We found that exposure of mice and rats to male but not female experimenters produces pain
inhibition. Male-related stimuli induced a robust physiological stress response that results …
inhibition. Male-related stimuli induced a robust physiological stress response that results …