Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation,
surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which …

Purpose Alterations in DNA damage response and repair (DDR) genes are associated with
increased mutation load and improved clinical outcomes in platinum-treated metastatic …

Mechanisms that control mobilization of cytosolic calcium [Ca 2+ ] i are key for regulation of
numerous eukaryotic cell functions. One such paradigmatic mechanism involves activation of …

… 13–17 settings, here we present the magnitude of imatinib's effect across the spectrum of
GIST presentation (PRIM, PRIM + MET, and MET) in the largest single-institution series of …

… You might also want to correct it for gender since there was a disproportion of females in your
series … ductal adenocarcinomas in some patients as has been shown in many other series? …

… To our knowledge, this is the largest Western series to evaluate comprehensively the utility
of preoperative serum inflammatory indices and their individual components for prediction of …

… We sought to study the largest series to date of ChRCC patients and evaluate clinical outcome
to determine prognostic factors for recurrence-free survival (RFS) and overall survival (OS)…

Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West
Africa is vital to addressing the regions rising burden of disease. Tissue from unselected …

… a multi-institutional retrospective series of 449 patients by de … associated with worse survival
in our series. IDH1/2 mutations … Conversely, in our series, loss of function in the CDKN2A/B …

Intra‐operative hypotension is a known predictor of adverse events and poor outcomes
following major surgery. Hypotension often occurs on induction of anaesthesia, typically …