The acute porphyrias, 4 inherited disorders of heme biosynthesis, cause life-threatening
attacks of neurovisceral symptoms that mimic many other acute medical and psychiatric …

Most iron in mammalian systems is routed to mitochondria to serve as a substrate for
ferrochelatase. Ferrochelatase inserts iron into protoporphyrin IX to form heme which is …

Transfusion therapy for inherited anemias and acquired refractory anemias both improves
the quality of life and prolongs survival. A consequence of chronic transfusion therapy is …

Colon cancer stem cells are believed to originate from a rare population of putative CD133
+ intestinal stem cells. Recent publications suggest that a small subset of colon cancer cells …

… We thank J. Nathans for the human retina cDNA library, M. Ehrlich for the rat striatal cDNA
library, M. Hnatowich for assistance with sequence comparisons, J. Lomasney for providing …

Cellular progenitors remain poorly characterized in many adult tissues, limited in part by the
lack of unbiased techniques to identify progenitors and their progeny. To address this …

Insulin resistance and diabetes might promote neurodegenerative disease, but a molecular
link between these disorders is unknown. Many factors are responsible for brain growth, …

There is evidence that iron loading and organ damage can be prevented in patients with
hemochromatosis if prophylactic phlebotomy is employed early in the disease — findings …

Although many signaling pathways have been shown to promote β-cell growth, surprisingly
little is known about the normal life cycle of preexisting β-cells or the signaling pathways …

Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing
divisions so that older (‘immortal’) DNA strands are retained in daughter stem cells whereas …