Based on the realization that N-alkyl 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones are tumor
necrosis factor-α antagonists, we discovered two additional classes of antagonists: 3-thioxo-2,…

1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were
identified from high through-put screening using encoded library technology. The triazine …

When exposed to a pathogen, a naive CD4 + T cell is forced to make a cell fate decision
that leads to a polarized population of Th1 IFN-γ– or Th2 IL-4– producing cells. Although IL-4 …

… Brown, Stephen HM PhD *,§ ; Gregory, Diane E. PhD * ; Carr, J. … SHM Brown and DE Gregory
were supported by NSERC … where the subscript D represents the degenerated L2–L3 or …

Ikaros, a hematopoietic transcription factor, has well defined effects on early lymphocyte
development in the bone marrow and thymus. In this study we demonstrate that Ikaros is a …

Once considered to be of sole importance in allergy and parasitic infections, the role of mast
cells in other pathologic and protective immune responses is becoming increasingly evident…

INTRODUCTION: Human papillomavirus (HPV) vaccine trials have demonstrated high efficacy
in preventing HPV infections and HPV related disease in females ages 16–26. However, …

A routinely used assumption when interpreting two-dimensional NMR spectra obtained with
a commonly used double-quantum (DQ) magic-angle-spining (MAS) pulse sequence …

An international consortium is sequencing the euchromatic genespace of Medicago truncatula.
Extensive bioinformatic and database resources support the marker-anchored bacterial …

Individuals with low back pain or injury (LBP/LBI) have been shown to display altered muscle
responses to trunk perturbations; however it is unclear whether these observations are a …