The discovery of rare genetic variants is accelerating, and clear guidelines for distinguishing
disease-causing sequence variants from the many potentially functional variants present in …

OBJECTIVES: This review examines the burden and patterns of disease in systemic lupus
erythematosus (SLE) and the influence and interactions of gender, ethnicity, age, and …

Autoimmune diseases are among the leading causes of death among young and middle-aged
women in the United States. Incidence rates vary among the autoimmune diseases, with …

We report the generation and analysis of functional data from multiple, diverse experiments
performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE …

… theories of rhythm... are... as well understood, and as much discussed as theories of harmony
and counterpoint... they will rest in no small measure on the foundations laid by Cooper …

… Let G be a belief-network structure, such that the variables in G are a subset of the variables …
in Q that contain G as a subgraph. We can calculate the posterior probability of G as follows: …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

Current methods for annotating and interpreting human genetic variation tend to exploit a
single information type (for example, conservation) and/or are restricted in scope (for example, …

… Cooper’s vision and masterful writing are what made this book the success it has been
through eight editions and his review and feedback on all edits and updates in this edition were …

… GF Cooper, The computational complexity of probabilistic inference using belief networks,
Rept. KSL-87-27, Medical Computer Science Group, Stanford University, Stanford, CA (1987). …