User profiles for Babak Javid

Babak Javid

University of California, San Francisco
Verified email at ucsf.edu
Cited by 2628

Mycobacterial mistranslation is necessary and sufficient for rifampicin phenotypic resistance

B Javid, F Sorrentino, M Toosky… - Proceedings of the …, 2014 - National Acad Sciences
Errors are inherent in all biological systems. Errors in protein translation are particularly
frequent giving rise to a collection of protein quasi-species, the diversity of which will vary …

[HTML][HTML] Antibodies and tuberculosis: finally coming of age?

H Li, B Javid - Nature Reviews Immunology, 2018 - nature.com
Are antibodies important for protection against tuberculosis? The jury has been out for more
than 100 years. B cell depletion in experimental Mycobacterium tuberculosis infection failed …

The essential mycobacterial amidotransferase GatCAB is a modulator of specific translational fidelity

…, D Moradigaravand, H Huang, BD Kana, B Javid - Nature …, 2016 - nature.com
Although regulation of translation fidelity is an essential process 1–7, diverse organisms and
organelles have differing requirements of translational accuracy 8–15, and errors in gene …

Selective translation by alternative bacterial ribosomes

…, JY Hong, S Sanyal, ZJ Lu, B Javid - Proceedings of the …, 2020 - National Acad Sciences
Alternative ribosome subunit proteins are prevalent in the genomes of diverse bacterial
species, but their functional significance is controversial. Attempts to study microbial ribosomal …

[HTML][HTML] The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis

…, A Bainomugisa, A Mandal, A Roohi, B Javid… - The Lancet …, 2022 - thelancet.com
Background Molecular diagnostics are considered the most promising route to achievement
of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC…

Covid-19: should the public wear face masks?

B Javid, MP Weekes, NJ Matheson - Bmj, 2020 - bmj.com
When covid-19 became a global health emergency, there was a visible contrast between the
responses of citizens in east Asia and the rest of the world. In east Asia, wearing of masks …

MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

…, S Alfonso, C Battilocchio, B Javid… - Antimicrobial agents …, 2012 - Am Soc Microbiol
The 1,5-diarylpyrrole derivative BM212 was previously shown to be active against multidrug-resistant
clinical isolates and Mycobacterium tuberculosis residing within macrophages as …

Structure and function: heat shock proteins and adaptive immunity

B Javid, PA MacAry, PJ Lehner - The Journal of Immunology, 2007 - journals.aai.org
Heat shock proteins (HSPs) have been implicated in the stimulation and generation of both
innate and adaptive immunity. The ability of HSPs to bind antigenic peptides and deliver …

Protein mistranslation: friend or foe?

…, MAS Santos, JH Zhu, PJ Farabaugh, B Javid - Trends in biochemical …, 2014 - cell.com
The translation of genes into functional proteins involves error. Mistranslation is a known
cause of disease, but, surprisingly, recent studies suggest that certain organisms from all …

Latently and uninfected healthcare workers exposed to TB make protective antibodies against Mycobacterium tuberculosis

…, Y Lu, M Cao, H Huang, B Javid - Proceedings of the …, 2017 - National Acad Sciences
The role of Igs in natural protection against infection by Mycobacterium tuberculosis (Mtb),
the causative agent of TB, is controversial. Although passive immunization with mAbs …