International asset and currency allocation
AF Lee - Journal of Portfolio Management, 1987 - search.proquest.com
A demonstration was performed to establish that portfolios constructed on the basis of the
separation between assets and currencies can be expected to outperform portfolios that do not …
separation between assets and currencies can be expected to outperform portfolios that do not …
[PDF][PDF] A general strategy for creating “inactive-conformation” abl inhibitors
B Okram, A Nagle, FJ Adrián, C Lee, P Ren, X Wang… - Chemistry & biology, 2006 - cell.com
Kinase inhibitors that bind to the ATP cleft can be broadly classified into two groups: those
that bind exclusively to the ATP site with the kinase assuming a conformation otherwise …
that bind exclusively to the ATP site with the kinase assuming a conformation otherwise …
A type-II kinase inhibitor capable of inhibiting the T315I “gatekeeper” mutant of Bcr-Abl
HG Choi, P Ren, F Adrian, F Sun, HS Lee… - Journal of medicinal …, 2010 - ACS Publications
The second generation of Bcr-Abl inhibitors nilotinib, dasatinib, and bosutinib developed to
override imatinib resistance are not active against the T315I “gatekeeper” mutation. Here we …
override imatinib resistance are not active against the T315I “gatekeeper” mutation. Here we …
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
In an effort to find new pharmacological modalities to overcome resistance to ATP-binding-site
inhibitors of Bcr–Abl, we recently reported the discovery of GNF-2, a selective allosteric …
inhibitors of Bcr–Abl, we recently reported the discovery of GNF-2, a selective allosteric …
[HTML][HTML] A specific interferon (IFN)-stimulated response element of the distal HLA-G promoter binds IFN-regulatory factor 1 and mediates enhancement of this …
S Lefebvre, S Berrih-Aknin, F Adrian, P Moreau… - Journal of Biological …, 2001 - ASBMB
Type I interferons display a broad range of immunomodulatory functions. Interferon β increases
gene expression at the transcriptional level through binding of factors to the interferon-…
gene expression at the transcriptional level through binding of factors to the interferon-…
[PDF][PDF] Synthesis and target identification of hymenialdisine analogs
Y Wan, W Hur, CY Cho, Y Liu, FJ Adrian, O Lozach… - Chemistry & biology, 2004 - cell.com
Hymenialdisine (HMD) is a sponge-derived natural product kinase inhibitor with nanomolar
activity against CDKs, Mek1, GSK3β, and CK1 and micromolar activity against Chk1. In order …
activity against CDKs, Mek1, GSK3β, and CK1 and micromolar activity against Chk1. In order …
[HTML][HTML] Selective inhibition of mutant isocitrate dehydrogenase 1 (IDH1) via disruption of a metal binding network by an allosteric small molecule
…, A Vassort, W Englaro, Y Li, V Patel, F Adrian… - Journal of Biological …, 2015 - ASBMB
Cancer-associated point mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2)
confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric …
confer a neomorphic enzymatic activity: the reduction of α-ketoglutarate to d-2-hydroxyglutaric …
Discovery of GNF-5837, a selective TRK inhibitor with efficacy in rodent cancer tumor models
P Albaugh, Y Fan, Y Mi, F Sun, F Adrian… - ACS Medicinal …, 2012 - ACS Publications
Neurotrophins and their receptors (TRKs) play key roles in the development of the nervous
system and the maintenance of the neural network. Accumulating evidence points to their …
system and the maintenance of the neural network. Accumulating evidence points to their …
Ba/F3 cells and their use in kinase drug discovery
…, S Kim, X Gu, G Xia, F Adrián - Current opinion in …, 2007 - journals.lww.com
Ba/F3 cells are an increasingly popular tool in kinase drug discovery. The ability to test the
transforming capacity of newly identified kinase mutations, and to profile drug candidates and …
transforming capacity of newly identified kinase mutations, and to profile drug candidates and …
[HTML][HTML] Glutaminase is essential for the growth of triple-negative breast cancer cells with a deregulated glutamine metabolism pathway and its suppression …
…, C Winter, V Richon, C Garcia-Escheverria, F Adrian… - PloS one, 2017 - journals.plos.org
Tumor cells display fundamental changes in metabolism and nutrient uptake in order to utilize
additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (…
additional nutrient sources to meet their enhanced bioenergetic requirements. Glutamine (…